Our meeting ended with 28 total Competitive Renewal & Career Starter grants for a total of $1,957,897 that was recommended by the SAC doctors and later that night approved by the KTEF SAC committee.
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This data will provide an essential molecular entry point from which to further develop methods to promote retinal regeneration through stem cell transplantation and likely have significant influence on the field of retinal regenerative medicine.
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His research and study will include another mouse model for RP, in which he will be able to model a prospective gene therapy strategy and perform a rigorous feasibility analysis with my cutting-edge microscopy techniques to see if this strategy could rescue and save the diseased retina.
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Juvenile glaucoma is usually caused by increased pressure inside the eye, which is due to resistance to the flow of the normal circulation of the fluid within the eye. The buildup of pressure in the eye can damage the visual sensing structures in the back of the eye, leading to blindness. The goal of this project is to better understand the mechanisms involved in the buildup of pressure in the eye. In his research he will be using human cells as well as a mouse model that has similar characteristics to those patients with juvenile glaucoma.
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The proposed research seeks to understand the critical signaling events with the MAPK network that bring about RGC death and thus reveal new targets for pediatric glaucoma intervention. It is our hope that these new insights will contribute to new treatment strategies to prevent vision loss.
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Congenital glaucoma is an eye disease that affects children between the ages of birth and three years. Although the disease is rare, it is one the significant causes of childhood blindness. Congenital glaucoma is usually caused by increased pressure inside the eye, which is due to developmental abnormalities in the front of the eye. The buildup of pressure in the eye compresses the visual sensing structures in the back of the eye, which leads to blindness. The goal of this project is to better understand the mechanisms involved in glaucomatous injury to the eye.
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Pediatric glaucoma is a potentially blinding disease, accounting for about 18% of blindness in blind institutions and 5% of overall pediatric blindness worldwide.
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Dr. Guo proposes to use a new CRISPR-based gene regulation technology to overcome these barriers and develop a novel type of gene therapy, with the longterm goal of generating new treatments for blinding diseases in children.
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This work will advance the understanding of the fundamental molecular mechanisms underlying fovea formation and contribute to the development of newer therapies for treating congenital foveal hypoplasia conditions.
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On October 10, 2020 at the 178th Annual Conclave in Ohio thanks to the generosity of the Sir Knights of Forest City Commandery No. 40 made a major contribution to make the Grand Commandery of Ohio now 200% Life Sponsorships.
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The goal of this project is to evaluate a novel technology, eye tracking, as a method for visual assessment in children with CVI. Eye tracking utilizes an infrared camera to capture eye movements while children view pictures and videos. This allows the doctor to non-invasively determine what a child with CVI is able to see, without requiring active participation.
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The goals of the study are to initially understand the cause of the disease by studying available models and test gene therapy to replace the defective gene to investigate whether this will prevent retinopathy in the disease model. The ultimate aim is to develop new therapies which will prevent vision loss in children affected by Danon disease.
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Xerophthalmia in vitamin A deficiency (VAD) is a major cause of pediatric blindness. Children with vitamin A deficiency develop severe corneal inflammation and opacification that can lead to blindness or loss of the eye.
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Funding for research in pediatric eye disorders is extremely important and critically needed. The Knights Templar Eye Foundation is one of the few organizations that provide support for pediatric ophthalmology research.
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A few short months ago, our world changed. But our obligation as Christian Masons has not. Whether we are assisting our shut-in brothers and neighbors with groceries or household chores or supporting doctors and scientists working to find a key that will allow a child who has never stared in amazement at a rainbow to see one for the first time, we always find a way to wrap others "in the broad mantle of a Mason's charity." There is no doubt in my mind we will continue to do so.
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Dr. Zhengping Hu from Schepens Eye Research Institute, Harvard Medical School in Boston, MA was awarded a $65,000 check to support her research in Retinopathy of Prematurity (ROP) which is a leading cause of blindness in premature and low birth weight infants.
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Many current and past grand officers of the Grand Commandery of Ohio along with many Constituent officers traveled to the Cole Eye Institute at the Cleveland Clinic to present a $65,000 research grant check to Joseph Fogerty, Ph.D., to study a common blinding disorder in children known as Leber’s Congenital Amaurosis (LCA)
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Dr. Kulkarni hypothesizes that the neural circuits activating the AII amacrine cells become abnormal during disease progression. These studies aim to identify the abnormal changes in the neural circuits, and thus reveal potential pharmacological targets that may allow them to silence aberrant activity while preserving the signals essential for vision. Knowledge from these studies is expected to inform the development of therapies for treating affected children.
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The Knights Templar Eye Foundation cannot express its gratitude sufficiently for the generous contributions from both Grand Commanderies. On behalf of the officers and trustees, the Foundation would like to thank each of these Grand Commanderies and congratulate them on their hard work and creativity in attaining 100 Life Sponsorship status.
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The KTEF executive committee, with the support of the KTEF board, has asked Dr. Bela Anand-Apte, MBBS, Ph.D. a current member of SAC, to serve as its chairman. The Foundation is very pleased to report that she has accepted.
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